Hormones are substances that regulate specific body functions, such as metabolism. ![]() “Attention should be given to possible masked renal damage in clinical practice for the management of CS,” they wrote. As part of the endocrine system, the adrenal glands produce hormones. The researchers also cautioned that kidney damage may go undetected in Cushing’s patients, and advised doctors to monitor for this possibility. “In conclusion,” the researchers wrote, “a persistent, but not progressive, significant decrease in eGFR was seen after adrenalectomy in patients with CS, as it was reported in patients with. Nevertheless, the study determined that Cushing’s patients experience a significant decrease in kidney function following adrenal gland removal. ![]() Additionally, higher levels of cortisol could be causing the elevated blood pressure measurement, explaining why the systolic blood pressure was higher in patients who experienced post-operative renal impairment. People with Cushing’s syndrome who undergo surgery to remove one or both adrenal glands experience a persistent decrease in kidney function after one month that does not seem to worsen or improve with time, a study has found. ![]() Therefore, the kidney damage experienced after surgery might be due to the sudden correcting of the excess filtration that comes from adrenal gland removal. Aldosterone can cause this in aldosteronism patients, and the researchers speculate that cortisol can cause this as well. From these data, the researchers suggested that a phenomenon called glomerular hyperfiltration was taking place: when the kidneys are performing, filtration functions at a higher rate than normal due to elevated hormones.
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